[PDF] Toxicity studies on an unripe Carica papaya aqueous extract: biochemical and haematological effects in wistar albino rats | Semantic Scholar (2024)

CPF aqueous extract significantly increased immune functions (IgG and IgM) while acrylamide significantly decrease it specially IgG, which suggests that acrieslamide-induced oxidative stress in rats can be ameliorated by administration of CPF aQueous extract.

The single oral dose of the CP leaf extract did not produce mortality or significant changes in the body weight, food and water consumption, and other biochemistry parameters demonstrated no significant changes as compared to the control.

The acute toxicity study reveals that the oral administration of the extract was found to be safe up to the dose level of 2000 mg/kg and the subacute study indicates that the extract is safe on the bone marrow function and it is neither hepatotoxic nor nephrotoxic, supporting the safety use of the aqueous extract of P. edulis in pharmacological studies.

In conclusion, UPAE do not cause acute toxicity on renal function through measurement of blood urea and creatinine levels.

It was concluded that the aqueous extract of C. glutinosum is safe for oral use at single dose of 2000 mg/kg bw and could therefore be continuously used by small breeders to control small ruminant helminthes.

The present work has revealed the toxicity of sub chronic administration of SYZ, which suggests that its prolonged usage must be avoided, according to the results of the biochemical investigations.

The microscopic exam of the liver of the animals treated chronically revealed intoxication for P. huberi .

Investigation of the hepatomodulatory effects of aqueous extracts of C. papaya leaf and unripe fruit at doses of 100 and 300 mg/kg on carbon tetrachloride (CCl4) and acetaminophen (ACM) and ACM-induced liver toxicities in rats indicates that aqueously extracts of the fruit may be useful in preventing CCl4 and ACm-induced Liver toxicities.

The results suggest that Anogeissus leiocarpus is a potent hepatoprotective and nephroprotective agent which is capable of normalizing biochemical abnormalities associated with liver and kidney damage.

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Investigations into antisickling and reversal of sickling activities of an aqueous extract of unripe pawpaw were carried out on blood from sickle cell patients using 2% sodium metabisulphite in a sickling test and it was concluded that extract ofUnripe Pawpaw really has antisickled agent and that this antisicksling agent lies in the ethyl acetate fraction of the extract.

Screening of crude extracts of the bark of Annona bullata showed cytotoxic and pesticidal activities and identified bullatacin as a diastereomer of asimicin, while the known compounds liriodenine and (-)-kaur-16-en-19-oic acid were lethal to brine shrimp but were not significantly cytot toxic.

In all cases where the acute toxicity testing is mainly concerned with the evaluation of toxicological potential of the test substances, the symptomatology following acute overdosing, and the knowledge of target organs of toxicity, the classical LD50-test should be replaced by a more comprehensive short term test that can be done with small numbers of animals.

Fractionation of the EtOH extract of the bark of Asimina triloba has led to the isolation and structural elucidation of a novel highly cytotoxic Annonaceous acetogenin, trilobacin.

A review of the data on 12 of the most commonly used herbs in the United States is provided and practical information and guidelines for the judicious use of medicinal herbs are provided.

Major medicinal plants, Major medicinal plants , کتابخانه دیجیتالی علوم پزشکی و خدمات شهید بهشتی.

The successor to Fundamentals, Textbook of Clinical Chemistry, follows an outline similar to the original text but adds many new subjects and updates older topics, resulting in a text that is 50% larger than its predecessor.

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