Antisickling agent in an extract of unripe pawpaw (Carica papaya): Is it real? | Semantic Scholar (2024)

The study showed that C. papaya fruit at different stages of ripening contains antisickling and sickling-reversal activities which may help reduce the associated complications of SCD when consumed by affected individuals.

Results indicate the possibility of C. papaya leaf extract as potential phytotherapy for sickle cell anemia and suggest the use of positive (phydroxybenzoic acid 5 μg /ml) and negative controls for the antisickling experiments.

Results indicate the possibility of C. papaya leaf extract as potential phytotherapy for sickle cell anemia and suggest the use of positive and negative controls for the antisickling experiments.

It was concluded that the aqueous extract of unripe Carica papaya has no adverse but beneficial effect on haematological parameters in sickle cell patients.

Results indicate the feasibility of C. papayaas an attractive potential candidate for SCD therapy, andFragiliograms indicated that the plant extract reduced hemolysis and protected erythrocyte membrane integrity under osmotic stress conditions.

Ethanol extracts of A. muricata, S. alata and D. regia may be helpful in the management of patients with sickle cell anemia and have the potential to reduce the sickling activity of Sickle cell blood.

Investigation into the antisickling activities of both crude methanol extracts and the aqueous fractions of the leaf, seed and seed pod of G. kola revealed the presence of saponins, tannins, combined and free anthraquinones, infer a preliminary confirmation for the effectiveness and use of Garcinia kola in the management of SCD and its implication in drug development.

Phytochemical screening of the plant extracts revealed the presence of saponnins, tannins and alkaloids that are justified in the treatment of SCD, and the implication of the results obtained in drug development for SCD management is discussed.

The findings from this study lends some credence to the folkloric claim that unripe papaya possesses antifertility properties and may therefore be considered as a potential source of contraceptives with very minimal or no side effects.

The roots of Plumbago zeylanica and Uvaria chamae, usedin folklore medicine in the management of sickle-cell disease in South-West Nigeria are justified and the role of each plant specimen in traditional recipes for SCD management and drugdevelopment is presented.

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The main active constituent was identified as a rearranged limonoid whose structure was recently elucidated and the in vitro antisickling activity was much higher at any concentrations and incubation conditions than with pentoxifylline used as standard.

This bark was evaluated for its antisickling properties using the method of Adesanya and Sofowora, and aqueous and methanolic extracts of the bark were partitioned between water and diethyl ether to give the ether fraction.

Results show that the aqueous methanol extract has potential use in the management of painful episodes experienced by sickle cell patients and is found to be concentration‐dependent.

Screening of crude extracts of the bark of Annona bullata showed cytotoxic and pesticidal activities and identified bullatacin as a diastereomer of asimicin, while the known compounds liriodenine and (-)-kaur-16-en-19-oic acid were lethal to brine shrimp but were not significantly cytot toxic.

Fractionation of the EtOH extract of the bark of Asimina triloba has led to the isolation and structural elucidation of a novel highly cytotoxic Annonaceous acetogenin, trilobacin.

Major medicinal plants, Major medicinal plants , کتابخانه دیجیتالی علوم پزشکی و خدمات شهید بهشتی.